Site de l'université de Franche-Comté
Francais Allemand

ISIFC is supported by internationally recognized research centers in the fields of engineering sciences, of microtechnology, of health and by research organizations (CNRS and INSERM). These research centers are in particular:


Logo Femto-ST

The Femto-ST Institute (Franche-Comté Electronics, MEchanics, Thermal and Optics - Science and Technology) is a joint research unit associated with the CNRS (UMR 6174) and attached together at the University of Franche-Comté (UFC), at the National School of Mechanics and Microtechnology (ENSMM), and at the University of Technology of Belfort-Montbéliard (UTBM).


The staff of Femto-ST is now about 650 people, including 325 permanents (230 researchers and teacher-researchers and 95 engineers, technicians and administrative staff). Research is conducted with the help of 225 doctoral students who get so a high-level training through research. 

(Source : Femto-ST website)


 More information on the web site of Femto-ST :


Teachers ISIFC are mostly members of Femto-ST. The 3rd year options are all supported by the research departments of Femto-ST :


  • The option “E-health” is directly linked with the Department of computer science of complex systems (DISC) and the Department of automatic and micro-mechatronic systems (AS2M), in particular with the teams "Distributed algorithmic collaboration, networks, optimization and scheduling "(CARTOON) and" Micro / nano-biomedical robotics "(MiNaRoB).
  • The option "Biomechanics and Microsystems"  is linked to the Department "Méc'Appli" (Applied Mechanics) and the Department of Optics, in particular with the teams "Mechanical and Physico-Chemical behavior of living tissues" (COTI), " Mems, Acoustics and Energy" (MEMS), "Interactions Material-process-Structure" (IMPS) and "Biophotonics" (BIO).
  • The option "Cellular and Tissular Engineering" is linked with the Department "Micro Nano Science & Systems" (MN2S) and especially with the team "Multiphysics Microsystems" (MIMU) with the French Blood Establishment (EFS), and with the Federative Institute of Research IFR133 (INSERM).

IFR 133

IFR 133

The IFR "Engineering for Cellular and Tissular Biology" brings together 10 research structures of the University of Franche-Comté, of INSERM and of the University Hospital of Besançon (1 UMR, 8 EA, 1 CIC-BT), around a scientific strategy with two main areas of development :


  • Research in the field of cellular and tissular engineering for therapeutic purposes, which is a recognized center of excellence of CHU; two areas are particularly investigated : cancerology and transplantation.
  • Research on macromolecular interactions with aspects of technological development around  biosensors and innovative biochromatographic technics, in correlation with applications, mainly in relation to the themes of carcinogenesis and of relationships pathogens - inflammation.


In total, the constitution of the IFR "Engineering for cellular and tissular Biology" can develop and implement a scientific policy based on a coherence and a synergy between the research components. This policy of pooling of intellectual and material resources increases the visibility of research activities,  facilitates the development and enhancement of scientific management of training. This is realized in conjunction with the Graduate School "Human, environment, health ", and in a more general and multidisciplinary framework with sectors of micro and nano-engineering or the sector of Engineering Sciences in the University of Franche-Comte.

(Source : IFR 133 website)


More information on the web site of IFR 133 :

The Universitary Hospital Centre and the DRCI


The Delegation of Clinical Research and Innovation (DRCI) prepares and implements the clinical research policy of the Hospital. It contributes to the definition of global research policy of the Hospital. It is through the DRCI that can be obtained the complete overview of Research at the University Hospital of Besançon, whether developed by CIC B (Clinical investigation center of Besancon) or outside. The DRCI implements all the rules of promotion and management of clinical research. It is responsible for driving the clinical research for an institutional promotion, the Hospital being sponsor or not. In addition, through the team "CEGEPs", the DRCI develops the French policy of recruitment in the clinical investigations for industry :  "more, faster and better".


The DRCI of the Universitary Hospital of Besançon is a member of the DIRC-East (Delegation for the clinical research in the East Regions in France).


(Source : CHRU of Besançon website)

 More information on the web site of CHU Besancon and DRCI :

The clinical investigation centers

CHU Besançon

The Universitary Hospital of Besancon has a Clinical Investigation Center with two specialties: the first one in Biotherapy (Inserm 506 CBT) with a labeling obtained in March 2005 and more recently the second one in Technological Innovations (Inserm CIT 808 - labeling obtained in January 2008). The Clinical Investigation Center of Besançon is integrated into the IFR 133 of the University of Franche-Comte.


The abbreviation CIC-BT is used for all the French clinical investigation centers specializing in biotherapy studies (therapeutic methods based on the use of living organisms or substances taken from living organisms). The CIC-BT is a technical medical center managed by Prof. Jean-Marc Chalopin within the Hospital, in close interaction with the platform of Biomonitoring (Prof. Philippe SAAS), the Inserm Unit 645 (Prof. Pierre TIBERGHIEN ) and the EFS Bourgogne / Franche-Comté.


Labelled in January 2008 by Inserm and DHOS, the Clinical Investigation Center for Technological Innovations of CHU Besançon has experienced rapid success. This is due to its specialization in the field of microtechnology for health which is in the scientific, industrial and medical context of Franche-Comte.


The CIC-IT of Besancon, led by Dr. Lionel Pazart, works in close partnership with the Femto-ST Institute (CNRS), with ISIFC, with EFS Bourgogne Franche-Comté, with the microtechnology cluster, with the innovative health technologies cluster and many other partners (users or patients associations, health care system, etc.).


The projects in which the CIC-IT has contributions, deal particularly with the following areas: devices for clinical investigation,  techniques of substitution, biological qualification and therapeutic methods of precision.


(Source : CHRU of Besançon website)


More information on the web site of CIC :  

L'Etablissement Français du Sang (French Blood Establishment)


Created on 1 January 2000, it is induced by the Act of 1 July 1998 that entirely reorganizes the French blood transfusion system. The French Blood Establishment is the only one civilian operator of blood transfusion in France. Its role is to ensure the link between the generosity of donors and the needs of patients.


EFS has a monopoly of blood transfusion in France since 2000. Blood transfusion includes the blood donation, the plasma donation and the platelet donation. The French Blood Establishment is the guarantor of the safety of the transfusion chain from donor to recipient. It helps to treat over 1 million patients each year. The French Blood is present in the territory (including DOM) with 152 collection sites and 40 000 mobile sites.


Under the supervision of the Ministry in charge of Health, its first public service mission is to ensure self-sufficiency in blood products in France with optimal conditions of security and quality. Firmly established in the territory through its 17 regional institutions, EFS covers, each year, the needs in blood products for a million patients, thanks to the generosity of blood donors, the professionalism of its staff and using a vast network of volunteers.


As part of the ISIFC training, students are required to work closely with the EFS, particularly in the context of tutored projects or the R & D cell.


(Source : EFS website)

 More information on the web site of EFS :  

Examples of research projects

Franche-Comté Medical Devices

The web site "Franche-Comté Medical devices" is a good way to get documents on the various medical research projects carried out within the institutes listed above (eg a wheelchair "intelligent" with recognition of obstacles, the treatment of tumors by an ultrasonic method, etc.).


These examples can be consulted at :